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PUBLICATIONS

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  • Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium. Liang, K, Barnett KC, Hsu M, Chou WC, Bais SS, Riebe K, Xie Y, Nguyen TT, Oguin TH 3rd, Vannella KM, Hewitt SM, Chertow DS, Blasi M, Sempowski GD, Karlsson A, Koller BH, Lenschow DJ, Randell SH, Ting JP. Sci Immunol. 2024 Jul 12. 9(97):eadn0178

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  • IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system. Seyedsadr M, Wang Y, Elzoheiry M, Shree Gopal S, Jang S, Duran G, Chervoneva I, Kasimoglou E, Wrobel JA, Hwang D, Garifallou J, Zhang X, Khan TH, Lorenz U, Su M, Ting JP, Broux B, Rostami A, Miskin D, Markovic-Plese S. Proc Natl Acad Sci U S A. 120(26):e2221007120, 2023.

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  • A 360° view of the inflammosome: Mechanisms of activation, cell death, and diseases. Barnett KC, Li S, Liang K, Ting JP. Cell 2023. 186(11):2288-2312.

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  • The NLR gene family: from discovery to present day. Chou WC, Jha S, Linhoff MW, Ting JP. Nat Rev Immunol. 2023.

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  • Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget's disease of bone. Hu X, Wong SW, Liang K, Wu TH, Wang S, Wang L, Liu J, Yamauchi M, Foster BL, Ting JP, Zhao B, Tseng HC, Ko CC. Sci Adv. 2023. 9(4):eade6998.

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  • An epithelial-immune circuit amplifies inflammasomes and IL-6 responses to SARS-CoV02. Barnett KC, Xie Y, Asakura T, Song, D, Liang K, Taft-Benz SA, Guo H, Yang S, Okuda K, Gilmore RC, Loome JF, Oguin Iii TH, Sempowski GD, Randell SH, Heise MT, Lei YL#, Boucher RC#, Ting JP#. #Co-senior authors. Cell Host Microbe. 2023. 31(2):243-259.

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  • STING-induced B regulatory cells compromise NK function in cancer immunity. Li S, Mirlekar B, Johnson BM, Brickey WJ, Wrobel JA, Yang N, Song D, Entwistle S, Tan X, Deng M, Cui Y, Li W, Vincent BG, Gale Jr M, Pylayeva-Gupta Y#, Ting JP#. #Co-senior authors. Nature. 2022. 610(7931):373-380.

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  • Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity. Mirlekar B, Wang Y, Li S, Zhou M, Entwistle S, De Buysscher T, Morrison A, Herrera G, Harris C, Vincent BG, Ting JP, Rashid N, Kim WY, Yeh J and Pylayeva-Gupta y. Cell Reports Medicine. 2022. 20;3(9): 100744.

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  • Zinc-c-di-AMP nanoparticles target and suppress tumors via endothelial STING1 activation and tumor association macrophage reinvigoration. Yang K, Han W, Jiang X, Piffko A, Bugno J, Han C, Li S, Liang H, Ting JP, Yang-Xin F, Lin W, Weichselbaum RR. Nature Nanotachnology 2022. doi: 10.1038/s41565-022-01225-x.

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  • Microparticle Delivery of a STING Agonist Enables Indirect Activation of NK Cells by Antigen-Presenting Cells. Watkins-Schulz R, Batt CJ, STiepel RT, Schmidt ME, Sandor AM, Chou WC, Ainslie KM, Bachelder EM, Ting JP. Mol Pharm 2022. 19(9): 3125-3138.

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  • Isolates of Salmonella typhimurium circumvent NLRP3 inflammasome recognition in macrophages during the chronic phase of infection. Cai D, Brickey WJ, Ting JP, Saf S. J Biol Chem. 2021. 298(1):101461.

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  • A Conversation with Dr. Jenny Ting. Ting, J. J Interferon Cytokine Res. 2021. 41(10):363-363.

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  • Re-Examination of the Exacerbating Effect of Inflammasome Components during Radiation Injury. Brickey WJ, Thompson WA, Sheng Z, Li Z, Owzar K, Ting JPY. Radiat Res. 2022. 197(2):199-203.

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  • Impact of intracellular innate immune receptors on immunometabolism. Chou WC, Rapanelli E, Li X, Ting JP. Cell Mol Immunol. 2022. 19(3):337-351.

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  • Move over NAIP, DDX17 diversifies the NLRC4 inflammasome. Barnett KC, Laing K. Ting JP. Sci Immunol. 2021. 6(66):eabm1201.

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  • Landscape and selection of vaccine epitopes in SARS-CoV-2. Smith CC, Olsen KS, Gentry KM, Sambade M, Beck W, Garness J, Entwistle S, Willis C, Vensko S, Woods A, Fini M, Carpenter B, Routh E, Kodysh J, O'Donnell T, Hager C, Heiss K, Stadler V, Garrison E, Sandor AM, Ting JPY, Weiss J, Krajewski K, Grant OC, Woods RJ, Heise M, Vincent BG, Ruinsteyn A. Genome Med. 2021 13(1): 101.

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  • Influenza Virus and SARS-CoV-2 Vaccines. Sandor AM, Sturdivant MS, Ting JP. J Immunol. 2021. 206(11):2509-2520.

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  • STING Agonist Mitigates Experimental Autoimmune Encephalomyelitis by Stimulating Type I IFN-Dependent and Independent Immune-Regulatory Pathways. Johnson BM, Uchimura T, Gallovic MD, Thamilarasan M, Chou WC, Gibson SA, Deng M, Tam JW, Batt CJ Williams J, Matsushima GK, Bachelder EM, Ainslie KM, Markovic-Plese S, Ting JP. J Immunol. 2021. 206(9):2015-2028.

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  • AIM2 in regulatory T cells restrains autoimmune diseases. Chou W-C, Guo Z, Guo H, chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E. Wang Y, Montgomery S, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY#, Ting JP#. #Co-senior authors. Nature 2021. 591(7849):300-305.

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  • Multi-omics analyses reveal that HIV-1 alters CD4 _ T cell immunometabolism to fuel virus replication. Guo H, Wang Q, Ghneim K, Wang L, Rampanelli E, Holley-Guthrie E, Cheng L, Garrido C, Margols DM, Eller LA, Robb ML, Sekaly RP, Chen X, Su L, Ting JP> Nat. Immunol. 2021. 22(4); 423-433.

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  • Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Guo H, Chou, W-C, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgovery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gones ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tax X, Sartor RB, Lu K, Ting JP. Science. 2020. 270(6516):eaay9097.

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  • Gut Mitocrobiota, NLR Proteins, and Intestinal Homeostasis. Guo H, Gibson SA, Ting JP. J Exp Med. 2020. 217(10):e20181832. Doi: 10.1084/jem.20181832.

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  • Inflammasome Assays in Vitro and in Mouse Models. Guo H, Ting JP. Curr Protoc Immunol. 2020. 131(1):e107. Doi:10.1002/cpim.107.

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  • DCAF1 regulates Treg senescence via the ROS axis during immunological aging. Guo Z, Wang G, Wu B, Chou WC, Cheng L, Zhou C, Lou J, Wu D, su L, Zheng J, Ting JP, Wan YY. J. Clin. Invest. 2020. 130(11): 5893-5908.

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  • TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Deng M, Tam JW, Wang L, Liang K, Li S, Zhang L, Guo H, Luo X, Zhang Y, Petrucelli A, Davis BK, Conti BJ, Brickey WJ, Ko CC, Lei YL, Sun S, Ting JP. Nat Commun. 2020. 11:2193. doi: 10.1038/s41467-020-16014-0.

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  • Mitochondrial GSDMD pores DAMPen Pyroptosis. Barnett KC and Ting JP. Immunity. 2020. 52(3):424-426.

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  • NLRP3-NEK7 inflammasome induction by a phospholipid, platelet activating factor (PAF), is independent of PAFR. Deng M, Guo H, Tam J, Johnson B, Brickey WJ, New J, Lenox A, Shi H, Golenbrock D, Koller, B, McKinnon K, Beutler B, and Ting JP. J Exp Med. 2019. 216(12): 2838-2853.

 

 

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  • The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Swanson KV, Deng M, Ting JP. Nat Rev Immunol. 2019 Aug;19(8):477-489. doi: 10.1038/s41577-019-0165-0.

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  • A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8+ T cell-mediated anti-tumor immunity. Watkins-Schulz R, Tiet P, Gallovic MD, Junkins RD, Batty C, Bachelder EM, Ainslie KM, Ting JPY. Biomaterials. 2019 Jun;205:94-105. doi: 10.1016/j.biomaterials.2019.03.011

 

  • NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP. Cell Host Microbe. 2019 Apr 10;25(4):602-616.e7. doi: 10.1016/j.chom.2019.02.013.

 

  • Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon. Li X, Deng M, Petrucelli AS, Zhu C, Mo J, Zhang L, Tam JW, Ariel P, Zhao B, Zhang S, Ke H, Li P, Dokholyan NV, Duncan JA, Ting JP. Immunity. 2019 Mar 19;50(3):591-599.e6. doi: 10.1016/j.immuni.2019.02.009.

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  • The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity. Uchimura T, Oyama Y, Deng M, Guo H, Wilson JE, Rampanelli E, Cook KD, Misumi I, Tan X, Chen L, Johnson B, Tam J, Chou WC, Brickey WJ, Petrucelli A, Whitmire JK, Ting JPY. Immunity. 2018 Dec 18;49(6):1049-1061.e6. doi: 10.1016/j.immuni.2018.10.008.

 

  • A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer. Cheng N, Watkins-Schulz R, Junkins RD, David CN, Johnson BM, Montgomery SA, Peine KJ, Darr DB, Yuan H, McKinnon KP, Liu Q, Miao L, Huang L, Bachelder EM, Ainslie KM, Ting JP. JCI Insight. 2018 Nov 15;3(22). pii: 120638. doi: 10.1172/jci.insight.120638.

 

  • Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists. Collier MA, Junkins RD, Gallovic MD, Johnson BM, Johnson MM, Macintyre AN, Sempowski GD, Bachelder EM, Ting JP, Ainslie KM. Mol Pharm. 2018 Nov 5;15(11):4933-4946. doi: 10.1021/acs.molpharmaceut.8b00579.

 

  • The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Truax AD, Chen L, Tam JW, Cheng N, Guo H, Koblansky AA, Chou WC, Wilson JE, Brickey WJ, Petrucelli A, Liu R, Cooper DE, Koenigsknecht MJ, Young VB, Netea MG, Stienstra R, Sartor RB, Montgomery SA, Coleman RA, Ting JP. Cell Host Microbe. 2018 Sep 12;24(3):364-378.e6. doi: 10.1016/j.chom.2018.08.009.

 

  • The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. Kurkjian CJ, Guo H, Montgomery ND, Cheng N, Yuan H, Merrill JR, Sempowski GD, Brickey WJ, Ting JP. Sci Rep. 2017 Dec 11;7(1):17355. doi: 10.1038/s41598-017-17729-9.

 

  • A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination. Junkins RD, Gallovic MD, Johnson BM, Collier MA, Watkins-Schulz R, Cheng N, David CN, McGee CE, Sempowski GD, Shterev I, McKinnon K, Bachelder EM, Ainslie KM, Ting JP. J Control Release. 2018 Jan 28;270:1-13. doi: 10.1016/j.jconrel.2017.11.030.

 

  • A noncanonical function of cGAMP in inflammasome priming and activation. Swanson KV, Junkins RD, Kurkjian CJ, Holley-Guthrie E, Pendse AA, El Morabiti R, Petrucelli A, Barber GN, Benedict CA, Ting JP. J Exp Med. 2017 Dec 4;214(12):3611-3626. doi: 10.1084/jem.20171749

 

  • NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP. J Exp Med. 2017 May 1;214(5):1351-1370. doi: 10.1084/jem.20150237.

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  • NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth. Chen L, Wilson JE, Koenigsknecht MJ, Chou WC, Montgomery SA, Truax AD, Brickey WJ, Packey CD, Maharshak N, Matsushima GK, Plevy SE, Young VB, Sartor RB, Ting JP. Nat Immunol. 2017 May;18(5):541-551. doi: 10.1038/ni.3690

 

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